Daily naltrexone dosing for AUD is which?

Daily naltrexone dosing for AUD is which?

• A. 50 mg once daily
• B. 150 mg monthly
• C. 2 mg daily
• D. 25 mg twice daily

Answer: (A)

Daily oral naltrexone dosing for AUD is 50 mg once daily. This amount provides sufficient mu-opioid receptor blockade to blunt the reinforcing effects of alcohol and help reduce cravings, while maintaining stable plasma levels over a 24-hour period for reliable protection each day. A dose of 2 mg daily is far too low to achieve effective receptor blockade, and 25 mg twice daily isn’t the standard regimen and hasn’t shown a clear advantage over a single daily dose. There is a long-acting injectable option given monthly, but that is a different formulation and not a daily oral schedule.

Daily oral naltrexone dosing for AUD is 50 mg once daily. This amount provides sufficient mu-opioid receptor blockade to blunt the reinforcing effects of alcohol and help reduce cravings, while maintaining stable plasma levels over a 24-hour period for reliable protection each day. A dose of 2 mg daily is far too low to achieve effective receptor blockade, and 25 mg twice daily isn’t the standard regimen and hasn’t shown a clear advantage over a single daily dose. There is a long-acting injectable option given monthly, but that is a different formulation and not a daily oral schedule.